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Chronic thromboembolic pulmonary hypertension is associated with a loss of total lung volume on computed tomography.
Tsuchiya, Nanae; Xu, Yan-Yan; Ito, Junji; Yamashiro, Tsuneo; Ikemiyagi, Hidekazu; Mummy, David; Schiebler, Mark L; Yonemoto, Koji; Murayama, Sadayuki; Nishie, Akihiro.
Affiliation
  • Tsuchiya N; Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara 903-0125, Okinawa, Japan. nanae7a50@hotmail.com.
  • Xu YY; Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Ito J; Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara 903-0125, Okinawa, Japan.
  • Yamashiro T; Department of Radiology, Yokohama City University, Yokohama 2360027, Japan.
  • Ikemiyagi H; Department of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Nishihara 9030125, Okinawa, Japan.
  • Mummy D; Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC 27710, United States.
  • Schiebler ML; Department of Radiology, University of Wisconsin-Madison, Madison, WI 53792, United States.
  • Yonemoto K; Department of Biostatistics, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Nishihara 903-0215, Okinawa, Japan.
  • Murayama S; Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara 903-0125, Okinawa, Japan.
  • Nishie A; Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara 903-0125, Okinawa, Japan.
World J Radiol ; 15(5): 146-156, 2023 May 28.
Article de En | MEDLINE | ID: mdl-37275304
BACKGROUND: Although lung volumes are usually normal in individuals with chronic thromboembolic pulmonary hypertension (CTEPH), approximately 20%-29% of patients exhibit a restrictive pattern on pulmonary function testing. AIM: To quantify longitudinal changes in lung volume and cardiac cross-sectional area (CSA) in patients with CTEPH. METHODS: In a retrospective cohort study of patients seen in our hospital between January 2012 and December 2019, we evaluated 15 patients with CTEPH who had chest computed tomography (CT) performed at baseline and after at least 6 mo of therapy. We matched the CTEPH cohort with 45 control patients by age, sex, and observation period. CT-based lung volumes and maximum cardiac CSAs were measured and compared using the Wilcoxon signed-rank test and the Mann-Whitney u test. RESULTS: Total, right lung, and right lower lobe volumes were significantly reduced in the CTEPH cohort at follow-up vs baseline (total, P = 0.004; right lung, P = 0.003; right lower lobe; P = 0.01). In the CTEPH group, the reduction in lung volume and cardiac CSA was significantly greater than the corresponding changes in the control group (total, P = 0.01; right lung, P = 0.007; right lower lobe, P = 0.01; CSA, P = 0.0002). There was a negative correlation between lung volume change and cardiac CSA change in the control group but not in the CTEPH cohort. CONCLUSION: After at least 6 mo of treatment, CT showed an unexpected loss of total lung volume in patients with CTEPH that may reflect continued parenchymal remodeling.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Observational_studies / Prognostic_studies / Risk_factors_studies Langue: En Journal: World J Radiol Année: 2023 Type de document: Article Pays d'affiliation: Japon Pays de publication: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Observational_studies / Prognostic_studies / Risk_factors_studies Langue: En Journal: World J Radiol Année: 2023 Type de document: Article Pays d'affiliation: Japon Pays de publication: États-Unis d'Amérique