Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.

Mikami, Yu; Grubb, Barbara R; Rogers, Troy D; Dang, Hong; Asakura, Takanori; Kota, Pradeep; Gilmore, Rodney C; Okuda, Kenichi; Morton, Lisa C; Sun, Ling; Chen, Gang; Wykoff, Jason A; Ehre, Camille; Vilar, Juan; van Heusden, Catharina; Livraghi-Butrico, Alessandra; Gentzsch, Martina; Button, Brian; Stutts, M Jackson; Randell, Scott H; O'Neal, Wanda K; Boucher, Richard C

Mikami, Yu; Grubb, Barbara R; Rogers, Troy D; Dang, Hong; Asakura, Takanori; Kota, Pradeep; Gilmore, Rodney C; Okuda, Kenichi; Morton, Lisa C; Sun, Ling; Chen, Gang; Wykoff, Jason A; Ehre, Camille; Vilar, Juan; van Heusden, Catharina; Livraghi-Butrico, Alessandra; Gentzsch, Martina; Button, Brian; Stutts, M Jackson; Randell, Scott H; O'Neal, Wanda K; Boucher, Richard C.

Affiliation

Mikami Y; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Grubb BR; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Rogers TD; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Dang H; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Asakura T; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Kota P; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Gilmore RC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Okuda K; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Morton LC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Sun L; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Chen G; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Wykoff JA; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Ehre C; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Vilar J; Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
van Heusden C; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Livraghi-Butrico A; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Gentzsch M; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Button B; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Stutts MJ; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Randell SH; Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
O'Neal WK; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Boucher RC; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Sci Transl Med ; 15(699): eabo7728, 2023 06 07.

Article de En | MEDLINE | ID: mdl-37285404

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Mucoviscidose / Broncho-pneumopathie chronique obstructive / COVID-19 Limites: Humans Langue: En Journal: Sci Transl Med Sujet du journal: CIENCIA / MEDICINA Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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