Cancer immunity derailed: PGE<sub>2</sub> misconducts cDC1s.

Brown, Matthew; Tran, Michelle A; Bhardwaj, Nina

Cancer immunity derailed: PGE₂ misconducts cDC1s.

Brown, Matthew; Tran, Michelle A; Bhardwaj, Nina.

Affiliation

Brown M; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tran MA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bhardwaj N; Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Extramural Member, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. Electronic address: nina.bhardwaj@mssm.edu.

Immunity ; 56(6): 1165-1167, 2023 06 13.

Article de En | MEDLINE | ID: mdl-37315532

ABSTRACT

ABSTRACT

Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Dinoprostone / Tumeurs Limites: Humans Langue: En Journal: Immunity Sujet du journal: ALERGIA E IMUNOLOGIA Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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