Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling.
Biochim Biophys Acta Rev Cancer
; 1878(5): 188940, 2023 09.
Article
de En
| MEDLINE
| ID: mdl-37331641
ABSTRACT
Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Fibroblastes associés au cancer
/
Tumeurs de la tête et du cou
Type d'étude:
Risk_factors_studies
Limites:
Humans
Langue:
En
Journal:
Biochim Biophys Acta Rev Cancer
Année:
2023
Type de document:
Article
Pays d'affiliation:
République tchèque