Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs.

Lui, Kathy Nga-Chu; Li, Zhixin; Lai, Frank Pui-Ling; Lau, Sin-Ting; Ngan, Elly Sau-Wai

Lui, Kathy Nga-Chu; Li, Zhixin; Lai, Frank Pui-Ling; Lau, Sin-Ting; Ngan, Elly Sau-Wai.

Affiliation

Lui KN; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.
Li Z; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.
Lai FP; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.
Lau ST; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.
Ngan ES; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR. Electronic address: engan@hku.hk.

Stem Cell Reports ; 18(7): 1500-1515, 2023 07 11.

Article de En | MEDLINE | ID: mdl-37352849

Sujet(s)
Mots clés

Breathing disorder; Congenital central hypoventilation syndrome; Human brainstem organoids; Human cerebral organoids; Human pluripotent stem cells; PHOX2B; PHOX2B-PARMs; Retrotrapezoid nucleus (RTN) neurons; carbon dioxide (CO2)-sensitive glutamatergic neurons

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Protéines à homéodomaine / Protéines Hedgehog Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Stem Cell Reports Année: 2023 Type de document: Article

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