Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1.
BMB Rep
; 56(7): 410-415, 2023 Jul.
Article
de En
| MEDLINE
| ID: mdl-37357535
ABSTRACT
Breast cancer has become the most common cancer among women worldwide. Among breast cancers, metastatic breast cancer is associated with the highest mortality rate. Twist1, one of the epithelial-mesenchymal transition-regulating transcription factors, is known to promote the intravasation of breast cancer cells into metastatic sites. Therefore, targeting Twist1 to develop anti-cancer drugs might be a valuable strategy. In this study, LY-290181 dose-dependently inhibited migration, invasion, and multicellular tumor spheroid invasion in breast cancer cell lines. These anti-cancer effects of LY-290181 were mediated through the down-regulation of Twist1 protein levels. LY-290181 inhibited extracellular signal-regulated kinase and c-Jun N-terminal kinase signaling pathways. Therefore, our findings suggest that LY-290181 may serve as a basis for future research and development of an anti-cancer agent targeting metastatic cancers. [BMB Reports 2023; 56(7) 410-415].
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs du sein
Limites:
Female
/
Humans
Langue:
En
Journal:
BMB Rep
Sujet du journal:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Année:
2023
Type de document:
Article