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Integrating sperm cell transcriptome and seminal plasma metabolome to analyze the molecular regulatory mechanism of sperm motility in Holstein stud bulls.
Li, Wenlong; Mi, Siyuan; Zhang, Jinning; Liu, Xueqin; Chen, Siqian; Liu, Shuli; Feng, Xia; Tang, Yongjie; Li, Yanhua; Liu, Lin; Fang, Lingzhao; Zhang, Shengli; Yu, Ying.
Affiliation
  • Li W; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs & National Engineering Laboratory for Animal Breeding, Department of Animal Breeding and Genetics, College of Animal Science and Technology, China Agricultural University, Beijing 100193, Chin
  • Mi S; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs & National Engineering Laboratory for Animal Breeding, Department of Animal Breeding and Genetics, College of Animal Science and Technology, China Agricultural University, Beijing 100193, Chin
  • Zhang J; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs & National Engineering Laboratory for Animal Breeding, Department of Animal Breeding and Genetics, College of Animal Science and Technology, China Agricultural University, Beijing 100193, Chin
  • Liu X; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs & National Engineering Laboratory for Animal Breeding, Department of Animal Breeding and Genetics, College of Animal Science and Technology, China Agricultural University, Beijing 100193, Chin
  • Chen S; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs & National Engineering Laboratory for Animal Breeding, Department of Animal Breeding and Genetics, College of Animal Science and Technology, China Agricultural University, Beijing 100193, Chin
  • Liu S; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs & National Engineering Laboratory for Animal Breeding, Department of Animal Breeding and Genetics, College of Animal Science and Technology, China Agricultural University, Beijing 100193, Chin
  • Feng X; School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China.
  • Tang Y; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs & National Engineering Laboratory for Animal Breeding, Department of Animal Breeding and Genetics, College of Animal Science and Technology, China Agricultural University, Beijing 100193, Chin
  • Li Y; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs & National Engineering Laboratory for Animal Breeding, Department of Animal Breeding and Genetics, College of Animal Science and Technology, China Agricultural University, Beijing 100193, Chin
  • Liu L; Beijing Dairy Cattle Center, Qinghe'nanzhen Deshengmenwai Road, Beijing 100192, China.
  • Fang L; Beijing Dairy Cattle Center, Qinghe'nanzhen Deshengmenwai Road, Beijing 100192, China.
  • Zhang S; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Yu Y; Center for Quantitative Genetics and Genomics (QGG), Aarhus University, Aarhus, Denmark.
J Anim Sci ; 1012023 Jan 03.
Article de En | MEDLINE | ID: mdl-37366074
A Holstein stud bull can produce thousands of doses of frozen semen, which are used to distribute its selected genetics to dairy herds all over the world. The semen quality of stud bulls has an impact on the economics of the breeding centers. Our previous study found that monozygotic twin stud bulls showed different semen quality traits and different transcriptomic profiles in sperm cells. The number of motile sperm per ejaculate (NMSPE) is an integrated trait for assessing sperm motility in stud bulls, which is one of the most important semen quality traits. In the present study, we selected 7 stud bulls that had a high NMSPE (named as H group) and 7 stud bulls with low NMSPE (named as L group) from a Chinese Holstein bull population based on 9 yr of semen quality records. In this study, we investigated the sperm cells transcriptomic differences between the two groups and observed the influences of seminal plasma metabolites on the transcriptomic profiles of the sperm cells. The results showed that the expression level of the differentially expressed genes in the sperm cells is closely related to NMSPE. Our study discovered 14 genes as the potential candidate markers for sperm motility, including FBXO39. Our data provide new insights into the improvement of bovine semen quality traits.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sperme / Analyse du sperme Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: J Anim Sci Année: 2023 Type de document: Article Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sperme / Analyse du sperme Type d'étude: Prognostic_studies Limites: Animals Langue: En Journal: J Anim Sci Année: 2023 Type de document: Article Pays de publication: États-Unis d'Amérique