Impact of Imprinted Immunity Induced by mRNA Vaccination in an Experimental Animal Model.
J Infect Dis
; 228(8): 1060-1065, 2023 10 18.
Article
de En
| MEDLINE
| ID: mdl-37369369
ABSTRACT
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants has led to concerns that ancestral SARS-CoV-2-based vaccines may not be effective against newly emerging Omicron subvariants. The concept of "imprinted immunity" suggests that individuals vaccinated with ancestral virus-based vaccines may not develop effective immunity against newly emerging Omicron subvariants, such as BQ.1.1 and XBB.1. In this study, we investigated this possibility using hamsters. Although natural infection induced effective antiviral immunity, breakthrough infections in hamsters with BQ.1.1 and XBB.1 Omicron subvariants after receiving the 3-dose mRNA-lipid nanoparticle vaccine resulted in only faintly induced humoral immunity, supporting the possibility of imprinted immunity.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
COVID-19
Limites:
Animals
/
Humans
Langue:
En
Journal:
J Infect Dis
Année:
2023
Type de document:
Article
Pays d'affiliation:
Japon