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Impact of Imprinted Immunity Induced by mRNA Vaccination in an Experimental Animal Model.
Fujita, Shigeru; Uriu, Keiya; Pan, Lin; Nao, Naganori; Tabata, Koshiro; Kishimoto, Mai; Itakura, Yukari; Sawa, Hirofumi; Kida, Izumi; Tamura, Tomokazu; Fukuhara, Takasuke; Ito, Jumpei; Matsuno, Keita; Sato, Kei.
Affiliation
  • Fujita S; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Uriu K; Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Pan L; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Nao N; Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Tabata K; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Kishimoto M; Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
  • Itakura Y; Division of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Sawa H; One Health Research Center, Hokkaido University, Sapporo, Japan.
  • Kida I; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Tamura T; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Fukuhara T; Division of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Ito J; One Health Research Center, Hokkaido University, Sapporo, Japan.
  • Matsuno K; Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.
  • Sato K; Institute for Vaccine Research and Development: HU-IVReD, Hokkaido University, Sapporo, Japan.
J Infect Dis ; 228(8): 1060-1065, 2023 10 18.
Article de En | MEDLINE | ID: mdl-37369369
ABSTRACT
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants has led to concerns that ancestral SARS-CoV-2-based vaccines may not be effective against newly emerging Omicron subvariants. The concept of "imprinted immunity" suggests that individuals vaccinated with ancestral virus-based vaccines may not develop effective immunity against newly emerging Omicron subvariants, such as BQ.1.1 and XBB.1. In this study, we investigated this possibility using hamsters. Although natural infection induced effective antiviral immunity, breakthrough infections in hamsters with BQ.1.1 and XBB.1 Omicron subvariants after receiving the 3-dose mRNA-lipid nanoparticle vaccine resulted in only faintly induced humoral immunity, supporting the possibility of imprinted immunity.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: COVID-19 Limites: Animals / Humans Langue: En Journal: J Infect Dis Année: 2023 Type de document: Article Pays d'affiliation: Japon
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: COVID-19 Limites: Animals / Humans Langue: En Journal: J Infect Dis Année: 2023 Type de document: Article Pays d'affiliation: Japon