Tofacitinib in pyoderma gangrenosum - A case series.
Int J Rheum Dis
; 27(1): e14810, 2024 Jan.
Article
de En
| MEDLINE
| ID: mdl-37395471
ABSTRACT
Pyoderma gangrenosum (PG) is a rare autoinflammatory disorder falling under the spectrum of neutrophilic dermatosis, characterized by distinctive skin ulceration which is non-infective, non-neoplastic and usually with no primary vasculitis. PG lesions are notorious for relapse and hence require multiple trials of medications often with prolonged and concomitant use of steroids. Due to lack of evidence-based studies on effective treatment options for PG, we have presented three isolated biopsy-proven PG cases who were successfully treated with Tofacitinib, a Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway inhibitor, without relapse in follow up.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pipéridines
/
Pyrimidines
/
Vascularite
/
Pyodermie phadégénique
Limites:
Humans
Langue:
En
Journal:
Int J Rheum Dis
Sujet du journal:
REUMATOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Inde
Pays de publication:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM