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HLA in isolated REM sleep behavior disorder and Lewy body dementia.
Yu, Eric; Krohn, Lynne; Ruskey, Jennifer A; Asayesh, Farnaz; Spiegelman, Dan; Shah, Zalak; Chia, Ruth; Arnulf, Isabelle; Hu, Michele T M; Montplaisir, Jacques Y; Gagnon, Jean-François; Desautels, Alex; Dauvilliers, Yves; Gigli, Gian Luigi; Valente, Mariarosaria; Janes, Francesco; Bernardini, Andrea; Högl, Birgit; Stefani, Ambra; Ibrahim, Abubaker; Heidbreder, Anna; Sonka, Karel; Dusek, Petr; Kemlink, David; Oertel, Wolfgang; Janzen, Annette; Plazzi, Giuseppe; Antelmi, Elena; Figorilli, Michela; Puligheddu, Monica; Mollenhauer, Brit; Trenkwalder, Claudia; Sixel-Döring, Friederike; Cochen De Cock, Valérie; Ferini-Strambi, Luigi; Dijkstra, Femke; Viaene, Mineke; Abril, Beatriz; Boeve, Bradley F; Rouleau, Guy A; Postuma, Ronald B; Scholz, Sonja W; Gan-Or, Ziv.
Affiliation
  • Yu E; Department of Human Genetics, McGill University, Montréal, Québec, Canada.
  • Krohn L; The Neuro (Montréal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.
  • Ruskey JA; Department of Human Genetics, McGill University, Montréal, Québec, Canada.
  • Asayesh F; The Neuro (Montréal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.
  • Spiegelman D; The Neuro (Montréal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.
  • Shah Z; Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
  • Chia R; The Neuro (Montréal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.
  • Arnulf I; Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
  • Hu MTM; The Neuro (Montréal Neurological Institute-Hospital), McGill University, Montréal, Québec, Canada.
  • Montplaisir JY; Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada.
  • Gagnon JF; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
  • Desautels A; Neuromuscular Diseases Research Section, National Institute on Aging, Bethesda, Maryland, USA.
  • Dauvilliers Y; Sleep Disorders Unit, Pitié Salpêtrière Hospital, Paris Brain Institute and Sorbonne University, Paris, France.
  • Gigli GL; Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK.
  • Valente M; Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Janes F; Center for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal - Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
  • Bernardini A; Department of Psychiatry, Université de Montréal, Montréal, Québec, Canada.
  • Högl B; Center for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal - Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
  • Stefani A; Department of Psychology, Université du Québec à Montréal, Montréal, Québec, Canada.
  • Ibrahim A; Center for Advanced Research in Sleep Medicine, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal - Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
  • Heidbreder A; Department of Neurosciences, Université de Montréal, Montréal, Québec, Canada.
  • Sonka K; National Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, Montpellier, France.
  • Dusek P; Clinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
  • Kemlink D; Department of Medicine (DAME), University of Udine, Udine, Italy.
  • Oertel W; Clinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
  • Janzen A; Department of Medicine (DAME), University of Udine, Udine, Italy.
  • Plazzi G; Clinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
  • Antelmi E; Clinical Neurology Unit, Department of Neurosciences, University Hospital of Udine, Udine, Italy.
  • Figorilli M; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Puligheddu M; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Mollenhauer B; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Trenkwalder C; Department for Sleep Medicine and Neuromuscular disease, University Hospital Muenster, Muenster, Germany.
  • Sixel-Döring F; Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
  • Cochen De Cock V; Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
  • Ferini-Strambi L; Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
  • Dijkstra F; Department of Neurology, Philipps University, Marburg, Germany.
  • Viaene M; Department of Neurology, Philipps University, Marburg, Germany.
  • Abril B; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio-Emilia, Modena, Italy.
  • Boeve BF; IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy.
  • Rouleau GA; Neurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
  • Postuma RB; Department of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy.
  • Scholz SW; Paracelsus-Elena-Klinik, Kassel, Germany.
  • Gan-Or Z; Department of Neurosurgery, University Medical Centre Göttingen, Göttingen, Germany.
Ann Clin Transl Neurol ; 10(9): 1682-1687, 2023 09.
Article de En | MEDLINE | ID: mdl-37401389
ABSTRACT
Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*1101 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie à corps de Lewy / Trouble du comportement en sommeil paradoxal / Synucléinopathies Limites: Humans Langue: En Journal: Ann Clin Transl Neurol Année: 2023 Type de document: Article Pays d'affiliation: Canada
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie à corps de Lewy / Trouble du comportement en sommeil paradoxal / Synucléinopathies Limites: Humans Langue: En Journal: Ann Clin Transl Neurol Année: 2023 Type de document: Article Pays d'affiliation: Canada