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Diabetes mellitus and risk of breast cancer: a large-scale, prospective, population-based study.
Xiong, Fanxiu; Wang, Jingxuan; Nierenberg, Jovia L; Van Blarigan, Erin L; Kenfield, Stacey A; Chan, June M; Schmajuk, Gabriela; Huang, Chiung-Yu; Graff, Rebecca E.
Affiliation
  • Xiong F; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Wang J; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Nierenberg JL; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Van Blarigan EL; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Kenfield SA; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
  • Chan JM; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
  • Schmajuk G; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Huang CY; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
  • Graff RE; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Br J Cancer ; 129(4): 648-655, 2023 09.
Article de En | MEDLINE | ID: mdl-37402868
BACKGROUND: The objective of this study was to evaluate associations of diabetes overall, type 1 diabetes (T1D), and type 2 diabetes (T2D) with breast cancer (BCa) risk. METHODS: We included 250,312 women aged 40-69 years between 2006 and 2010 from the UK Biobank cohort. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) were calculated for associations of diabetes and its two major types with the time from enrollment to incident BCa. RESULTS: We identified 8182 BCa cases during a median follow-up of 11.1 years. We found no overall association between diabetes and BCa risk (aHR = 1.02, 95% CI = 0.92-1.14). When accounting for diabetes subtype, women with T1D had a higher risk of BCa than women without diabetes (aHR = 1.52, 95% CI = 1.03-2.23). T2D was not associated with BCa risk overall (aHR = 1.00, 95% CI = 0.90-1.12). However, there was a significantly increased risk of BCa in the short time window after T2D diagnosis. CONCLUSIONS: Though we did not find an association between diabetes and BCa risk overall, an increased risk of BCa was observed shortly after T2D diagnosis. In addition, our data suggest that women with T1D may have an increased risk of BCa.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du sein / Diabète de type 1 / Diabète de type 2 Type d'étude: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Female / Humans Langue: En Journal: Br J Cancer Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du sein / Diabète de type 1 / Diabète de type 2 Type d'étude: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Female / Humans Langue: En Journal: Br J Cancer Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni