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Natural products as the calcium channel blockers for the treatment of arrhythmia: Advance and prospect.
Xiao, Lu; Chen, Xing-Juan; Feng, Ji-Kang; Li, Wei-Na; Yuan, Shuo; Hu, Ying.
Affiliation
  • Xiao L; China Academy of Chinese Medical Sciences Guang'anmen Hospital, Beijing 100053, China.
  • Chen XJ; China Academy of Chinese Medical Sciences Guang'anmen Hospital, Beijing 100053, China.
  • Feng JK; Linyi Zhengzhi Hospital, Linyi 276004, China.
  • Li WN; China Academy of Chinese Medical Sciences Guang'anmen Hospital, Beijing 100053, China.
  • Yuan S; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou 450018, China. Electronic address: zzuyuanshuo@163.com.
  • Hu Y; China Academy of Chinese Medical Sciences Guang'anmen Hospital, Beijing 100053, China; Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: huyingdr@126.com.
Fitoterapia ; 169: 105600, 2023 Sep.
Article de En | MEDLINE | ID: mdl-37419421
Arrhythmia is one of the commonly heart diseases with observed abnormal heart-beat rhythm that caused by the obstacles of cardiac activity and conduction. The arrhythmic pathogenesis is complex and capricious and related with other cardiovascular diseases that may lead to heart failure and sudden death. In particular, calcium overload is recognized as the main reason causing arrhythmia through inducing apoptosis in cardiomyocytes. Moreover, calcium channel blockers have been widely used as the routine drugs for the treatment of arrhythmia, but the different arrhythmic complications and adverse effects limit their further applications and demand new drug discovery. Natural products have always been the rich minerals for the development of new drugs that could be employed as the versatile player for the discovery of safe and effective anti-arrhythmia drugs with new mechanisms. In this review, we summarized natural products with the activity against calcium signaling and the relevant mechanism of actions. We are expected to provide an inspiration for the pharmaceutical chemists to develop more potent calcium channel blockers for the treatment of arrhythmia.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Produits biologiques / Inhibiteurs des canaux calciques Limites: Humans Langue: En Journal: Fitoterapia Année: 2023 Type de document: Article Pays d'affiliation: Chine Pays de publication: Pays-Bas

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Produits biologiques / Inhibiteurs des canaux calciques Limites: Humans Langue: En Journal: Fitoterapia Année: 2023 Type de document: Article Pays d'affiliation: Chine Pays de publication: Pays-Bas