Structure-Guided Chemical Optimization of Bicyclic Peptide (<i>Bicycle</i>) Inhibitors of Angiotensin-Converting Enzyme 2.

Harman, Maximilian A J; Stanway, Steven J; Scott, Heather; Demydchuk, Yuliya; Bezerra, Gustavo Arruda; Pellegrino, Simone; Chen, Liuhong; Brear, Paul; Lulla, Aleksei; Hyvönen, Marko; Beswick, Paul J; Skynner, Michael J

Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2.

Harman, Maximilian A J; Stanway, Steven J; Scott, Heather; Demydchuk, Yuliya; Bezerra, Gustavo Arruda; Pellegrino, Simone; Chen, Liuhong; Brear, Paul; Lulla, Aleksei; Hyvönen, Marko; Beswick, Paul J; Skynner, Michael J.

Affiliation

Harman MAJ; BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.
Stanway SJ; BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.
Scott H; BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.
Demydchuk Y; BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.
Bezerra GA; BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.
Pellegrino S; BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.
Chen L; BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.
Brear P; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Lulla A; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Hyvönen M; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Beswick PJ; BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.
Skynner MJ; BicycleTx Ltd., Portway Building Blocks A and B, Granta Park, Great Abington, Cambridge CB21 6GS, U.K.

J Med Chem ; 66(14): 9881-9893, 2023 07 27.

Article de En | MEDLINE | ID: mdl-37433017

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Carboxypeptidases / Angiotensin-converting enzyme 2 Limites: Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2023 Type de document: Article Pays d'affiliation: Royaume-Uni

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