Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening.

Deng, Dexin; Yang, Yingxue; Zou, Yurong; Liu, Kongjun; Zhang, Chufeng; Tang, Minghai; Yang, Tao; Chen, Yong; Yuan, Xue; Guo, Yong; Zhang, Shunjie; Si, Wenting; Peng, Bin; Xu, Qing; He, Wen; Xu, Dingguo; Xiang, Mingli; Chen, Lijuan

Deng, Dexin; Yang, Yingxue; Zou, Yurong; Liu, Kongjun; Zhang, Chufeng; Tang, Minghai; Yang, Tao; Chen, Yong; Yuan, Xue; Guo, Yong; Zhang, Shunjie; Si, Wenting; Peng, Bin; Xu, Qing; He, Wen; Xu, Dingguo; Xiang, Mingli; Chen, Lijuan.

Affiliation

Deng D; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Yang Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Zou Y; MOE Key Laboratory of Green Chemistry and Technology, College of Chemistry, Sichuan University, Chengdu, Sichuan610064, P.R. China.
Liu K; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Zhang C; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Tang M; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Yang T; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Chen Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Yuan X; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Guo Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Zhang S; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Si W; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Peng B; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Xu Q; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
He W; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Xu D; MOE Key Laboratory of Green Chemistry and Technology, College of Chemistry, Sichuan University, Chengdu, Sichuan610064, P.R. China.
Xiang M; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.
Chen L; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu610041, China.

J Med Chem ; 66(14): 9495-9518, 2023 07 27.

Article de En | MEDLINE | ID: mdl-37438997

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Quinoxalines / Tumeurs Type d'étude: Diagnostic_studies / Screening_studies Limites: Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2023 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique

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