Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism.
Cold Spring Harb Perspect Med
; 2023 Jul 17.
Article
de En
| MEDLINE
| ID: mdl-37460158
ABSTRACT
Retinitis pigmentosa is a blinding disease wherein rod photoreceptors are affected first, due to the expression of a disease gene, leading to the loss of dim light vision. In many cases, cones do not express the disease gene, yet they are also affected and eventually die, typically after most of the rods in their neighborhood have died. The cause of secondary cone death is unclear. Photoreceptors are one of the most energy-demanding cell types in the body and consume a high amount of glucose. At an early stage of degeneration, the cones appear to have a shortage of glucose to fuel their metabolism. This review focuses on gene therapy approaches that address this potential metabolic shortcoming.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Cold Spring Harb Perspect Med
Année:
2023
Type de document:
Article