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Do astrocytes act as immune cells after pediatric TBI?
Panchenko, Polina E; Hippauf, Lea; Konsman, Jan Pieter; Badaut, Jerome.
Affiliation
  • Panchenko PE; CNRS UMR 5536 RMSB-University of Bordeaux, Bordeaux, France.
  • Hippauf L; CNRS UMR 5536 RMSB-University of Bordeaux, Bordeaux, France.
  • Konsman JP; CNRS UMR 5164, ImmunoConcEpT, University of Bordeaux, France.
  • Badaut J; CNRS UMR 5536 RMSB-University of Bordeaux, Bordeaux, France; Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address: jerome.badaut@cnrs.fr.
Neurobiol Dis ; 185: 106231, 2023 09.
Article de En | MEDLINE | ID: mdl-37468048
ABSTRACT
Astrocytes are in contact with the vasculature, neurons, oligodendrocytes and microglia, forming a local network with various functions critical for brain homeostasis. One of the primary responders to brain injury are astrocytes as they detect neuronal and vascular damage, change their phenotype with morphological, proteomic and transcriptomic transformations for an adaptive response. The role of astrocytic responses in brain dysfunction is not fully elucidated in adult, and even less described in the developing brain. Children are vulnerable to traumatic brain injury (TBI), which represents a leading cause of death and disability in the pediatric population. Pediatric brain trauma, even with mild severity, can lead to long-term health complications, such as cognitive impairments, emotional disorders and social dysfunction later in life. To date, the underlying pathophysiology is still not fully understood. In this review, we focus on the astrocytic response in pediatric TBI and propose a potential immune role of the astrocyte in response to trauma. We discuss the contribution of astrocytes in the local inflammatory cascades and secretion of various immunomodulatory factors involved in the recruitment of local microglial cells and peripheral immune cells through cerebral blood vessels. Taken together, we propose that early changes in the astrocytic phenotype can alter normal development of the brain, with long-term consequences on neurological outcomes, as described in preclinical models and patients.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Lésions encéphaliques / Lésions traumatiques de l'encéphale Type d'étude: Prognostic_studies Limites: Child / Humans Langue: En Journal: Neurobiol Dis Sujet du journal: NEUROLOGIA Année: 2023 Type de document: Article Pays d'affiliation: France

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Lésions encéphaliques / Lésions traumatiques de l'encéphale Type d'étude: Prognostic_studies Limites: Child / Humans Langue: En Journal: Neurobiol Dis Sujet du journal: NEUROLOGIA Année: 2023 Type de document: Article Pays d'affiliation: France
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