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Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study.
Green, Charles E; Tyson, Jon E; Heyne, Roy J; Hintz, Susan R; Vohr, Betty R; Bann, Carla M; Das, Abhik; Bell, Edward F; Debsareea, Sana Boral; Stephens, Emily; Gantz, Marie G; Petrie Huitema, Carolyn M; Johnson, Karen J; Watterberg, Kristi L; Mosquera, Ricardo; Peralta-Carcelen, Myriam; Wilson-Costello, Deanne E; Colaizy, Tarah T; Maitre, Nathalie L; Merhar, Stephanie L; Adams-Chapman, Ira; Fuller, Janell; Hartley-McAndrew, Michelle E; Malcolm, William F; Winter, Sarah; Duncan, Andrea F; Myer, Gary J; Kicklighter, Stephen D; Wyckoff, Myra H; DeMauro, Sara B; Hibbs, Anna Maria; Stoll, Barbara J; Carlo, Waldemar A; Van Meurs, Krisa P; Rysavy, Matthew A; Patel, Ravi M; Sánchez, Pablo J; Laptook, Abbot R; Cotten, C Michael; D'Angio, Carl T; Walsh, Michele C.
Affiliation
  • Green CE; Department of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA. Charles.Green@uth.tmc.edu.
  • Tyson JE; Department of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Heyne RJ; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Hintz SR; Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
  • Vohr BR; Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA.
  • Bann CM; Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, Greensboro, NC, USA.
  • Das A; Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.
  • Bell EF; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
  • Debsareea SB; Center for Clinical Research and Evidence-Based Medicine, University of Texas Houston McGovern Medical School, Houston, TX, USA.
  • Stephens E; Department of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Gantz MG; Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, Greensboro, NC, USA.
  • Petrie Huitema CM; Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.
  • Johnson KJ; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
  • Watterberg KL; University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
  • Mosquera R; Children's Memorial Hermann Hospital, Houston, TX, USA.
  • Peralta-Carcelen M; Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Wilson-Costello DE; Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
  • Colaizy TT; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
  • Maitre NL; Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.
  • Merhar SL; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Adams-Chapman I; Emory University School of Medicine, Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Fuller J; Department of Pediatrics, University of New Mexico, Albuquerque, NM, USA.
  • Hartley-McAndrew ME; Department of Pediatrics, University of Buffalo, Buffalo, NY, USA.
  • Malcolm WF; Department of Pediatrics, Duke University, Durham, NC, USA.
  • Winter S; Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Duncan AF; Department of Pediatrics, Pennsylvania Hospital, Philadelphia, PA, USA.
  • Myer GJ; University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
  • Kicklighter SD; Department of Pediatrics, Wake Medical Center, Raleigh, NC, USA.
  • Wyckoff MH; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • DeMauro SB; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.
  • Hibbs AM; Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
  • Stoll BJ; Department of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Carlo WA; Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Van Meurs KP; Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
  • Rysavy MA; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
  • Patel RM; Emory University School of Medicine, Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Sánchez PJ; Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.
  • Laptook AR; Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA.
  • Cotten CM; Department of Pediatrics, Duke University, Durham, NC, USA.
  • D'Angio CT; Department of Pediatrics, Wake Medical Center, Raleigh, NC, USA.
  • Walsh MC; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
J Perinatol ; 43(11): 1398-1405, 2023 11.
Article de En | MEDLINE | ID: mdl-37542155
ABSTRACT

OBJECTIVE:

Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. STUDY

DESIGN:

Blinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age.

RESULTS:

We assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56-2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics.

CONCLUSION:

Impairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. GOV ID Term Reference (under the Generic Database Study) NCT00063063.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Développement de l'enfant / Très grand prématuré Type d'étude: Clinical_trials Limites: Humans / Infant / Newborn Langue: En Journal: J Perinatol Sujet du journal: PERINATOLOGIA Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Développement de l'enfant / Très grand prématuré Type d'étude: Clinical_trials Limites: Humans / Infant / Newborn Langue: En Journal: J Perinatol Sujet du journal: PERINATOLOGIA Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique