Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against &#945;-synuclein oligomers/protofibrils.

Ekmark-Lewén, S; Aniszewska, A; Molisak, A; Gumucio, A; Lindström, V; Kahle, P J; Nordström, E; Möller, C; Fälting, J; Lannfelt, L; Bergström, J; Ingelsson, M

Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils.

Ekmark-Lewén, S; Aniszewska, A; Molisak, A; Gumucio, A; Lindström, V; Kahle, P J; Nordström, E; Möller, C; Fälting, J; Lannfelt, L; Bergström, J; Ingelsson, M.

Affiliation

Ekmark-Lewén S; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.
Aniszewska A; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.
Molisak A; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.
Gumucio A; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.
Lindström V; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.
Kahle PJ; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, Tübingen, Germany.
Nordström E; BioArctic AB, Stockholm, Sweden.
Möller C; BioArctic AB, Stockholm, Sweden.
Fälting J; BioArctic AB, Stockholm, Sweden.
Lannfelt L; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.
Bergström J; BioArctic AB, Stockholm, Sweden.
Ingelsson M; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.

Aging Brain ; 4: 100086, 2023.

Article de En | MEDLINE | ID: mdl-37559953

Mots clés

Alpha-synuclein transgenic mice; Behavioral outcome; Immunotherapy; Oligomer/protofibril-selective antibody; Oligomers

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Clinical_trials / Diagnostic_studies / Risk_factors_studies Langue: En Journal: Aging Brain Année: 2023 Type de document: Article Pays d'affiliation: Suède Pays de publication: Pays-Bas

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