A Split-Face Study to Evaluate Efficacy of Autologous Injectable Platelet-Rich Fibrin With Microneedling Against Microneedling With Normal Saline (Placebo Control) in Atrophic Acne Scars.
Dermatol Surg
; 49(10): 938-942, 2023 10 01.
Article
de En
| MEDLINE
| ID: mdl-37584506
ABSTRACT
BACKGROUND:
Acne scars cause significant psychosocial stress. Despite a wide armamentarium, there is a constant search for an effective modality. Autologous injectable platelet-rich fibrin (i-PRF) is a promising novel option in the management of atrophic scars.OBJECTIVE:
To compare efficacy of autologous i-PRF with microneedling against microneedling alone in atrophic acne scars. MATERIALS ANDMETHODS:
A split-face prospective interventional study was conducted on 40 patients with atrophic acne scars. Autologous i-PRF and normal saline were injected into each scar on right (study) and left (control) sides, respectively, followed by microneedling on both sides. Four sessions were performed at monthly intervals with follow-up at 2 months. For assessment, Goodman and Baron (GB) scale, physician subjective score, and patient satisfaction scores were used.RESULTS:
Mean baseline GB grade on each side was 3.45. At 24 weeks, mean GB grade was significantly reduced on the study side (1.47, SD 0.56) than control side (3.33, SD 0.53). Mean patient satisfaction score was significantly higher on the right side (5.95) compared with the left side (5.35). Rolling scars responded the best followed by boxcar and ice-pick scars.CONCLUSION:
Autologous i-PRF and microneedling act synergistically to improve acne scars.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Techniques cosmétiques
/
Acné juvénile
/
Maladies du tissu conjonctif
/
Plasma riche en plaquettes
/
Fibrine riche en plaquettes
Type d'étude:
Clinical_trials
Limites:
Humans
Langue:
En
Journal:
Dermatol Surg
Sujet du journal:
DERMATOLOGIA
Année:
2023
Type de document:
Article
Pays d'affiliation:
Inde