Discovery of a First-in-Class Degrader for the Lipid Kinase PIKfyve.

Li, Chungen; Qiao, Yuanyuan; Jiang, Xia; Liu, Lianchao; Zheng, Yang; Qiu, Yudi; Cheng, Caleb; Zhou, Fengtao; Zhou, Yang; Huang, Weixue; Ren, Xiaomei; Wang, Yuzhuo; Wang, Zhen; Chinnaiyan, Arul M; Ding, Ke

Li, Chungen; Qiao, Yuanyuan; Jiang, Xia; Liu, Lianchao; Zheng, Yang; Qiu, Yudi; Cheng, Caleb; Zhou, Fengtao; Zhou, Yang; Huang, Weixue; Ren, Xiaomei; Wang, Yuzhuo; Wang, Zhen; Chinnaiyan, Arul M; Ding, Ke.

Affiliation

Li C; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Roadd, Shanghai 200032, People's Republic of China.
Qiao Y; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Jiang X; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Liu L; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Zheng Y; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Roadd, Shanghai 200032, People's Republic of China.
Qiu Y; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Cheng C; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Roadd, Shanghai 200032, People's Republic of China.
Zhou F; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Zhou Y; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, College of Pharmacy, Jinan University, 855 Xingye Avenue East, Guangzhou 5114
Huang W; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, College of Pharmacy, Jinan University, 855 Xingye Avenue East, Guangzhou 5114
Ren X; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Roadd, Shanghai 200032, People's Republic of China.
Wang Y; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Roadd, Shanghai 200032, People's Republic of China.
Wang Z; The Vancouver Prostate Centre, Vancouver General Hospital and Department of Urologic Sciences, The University of British Columbia, Vancouver, British Columbia V6H 3Z6, Canada.
Chinnaiyan AM; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, #345 Lingling Roadd, Shanghai 200032, People's Republic of China.
Ding K; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.

J Med Chem ; 66(17): 12432-12445, 2023 09 14.

Article de En | MEDLINE | ID: mdl-37605297

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs de la prostate Limites: Humans / Male Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2023 Type de document: Article Pays de publication: États-Unis d'Amérique

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