Altered sleep architecture in diabetes and prediabetes: findings from the Baependi Heart Study.
Sleep
; 47(1)2024 01 11.
Article
de En
| MEDLINE
| ID: mdl-37658822
ABSTRACT
STUDY OBJECTIVES:
People with diabetes and prediabetes are more likely to have sleep-disordered breathing (SDB), but few studies examined sleep architecture in people with diabetes or prediabetes in the absence of moderate-severe SDB, which was the aim of our cross-sectional study.METHODS:
This cross-sectional sample is from the Baependi Heart Study, a family-based cohort of adults in Brazil. About 1074 participants underwent at-home polysomnography (PSG). Diabetes was defined as fasting glucoseâ >125 mg/dL or HbA1câ >â 6.4 mmol/mol or taking diabetic medication, and prediabetes was defined as HbA1câ ≥â 5.7 & <6.5 mmol/mol or fasting glucoseâ ≥â 100 & ≤125 mg/dl. We excluded participants with an apnea-hypopnea index (AHI)â ≥â 30 in primary analyses andâ ≥â 15 in secondary analysis. We compared sleep stages among the 3 diabetes groups (prediabetes, diabetes, neither).RESULTS:
Compared to those without diabetes, we found shorter REM duration for participants with diabetes (-6.7 min, 95%CI -13.2, -0.1) and prediabetes (-5.9 min, 95%CI -10.5, -1.3), even after adjusting for age, gender, BMI, and AHI. Diabetes was also associated with lower total sleep time (-13.7 min, 95%CI -26.8, -0.6), longer slow-wave sleep (N3) duration (+7.6 min, 95%CI 0.6, 14.6) and higher N3 percentage (+2.4%, 95%CI 0.6, 4.2), compared to those without diabetes. Results were similar when restricting to AHIâ <â 15.CONCLUSIONS:
People with diabetes and prediabetes had less REM sleep than people without either condition. People with diabetes also had more N3 sleep. These results suggest that diabetes and prediabetes are associated with differences in sleep architecture, even in the absence of moderate-severe sleep apnea.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
État prédiabétique
/
Syndromes d'apnées du sommeil
/
Diabète
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limites:
Adult
/
Humans
Langue:
En
Journal:
Sleep
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique