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Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer.
Xiang, Weiguo; Zhao, Lijie; Han, Xin; Xu, Tianfeng; Kregel, Steven; Wang, Mi; Miao, Bukeyan; Qin, Chong; Wang, Mingliang; McEachern, Donna; Lu, Jianfeng; Bai, Longchuan; Yang, Chao-Yie; Kirchhoff, Paul D; Takyi-Williams, John; Wang, Lu; Wen, Bo; Sun, Duxin; Ator, Mark; Mckean, Robert; Chinnaiyan, Arul M; Wang, Shaomeng.
Affiliation
  • Xiang W; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Zhao L; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Han X; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Xu T; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Kregel S; Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang M; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Miao B; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Qin C; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang M; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • McEachern D; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Lu J; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Bai L; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Yang CY; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Kirchhoff PD; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Takyi-Williams J; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang L; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wen B; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Sun D; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Ator M; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Mckean R; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Chinnaiyan AM; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang S; Oncopia Therapeutics Inc, 2 West Liberty Blvd., Malvern, Pennsylvania 19355, United States.
J Med Chem ; 66(18): 13280-13303, 2023 Sep 28.
Article de En | MEDLINE | ID: mdl-37683104
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique