Gross and Histologic Placental Abnormalities Associated With Neonatal Hypoxic-Ischemic Encephalopathy.
Pediatr Dev Pathol
; 27(2): 123-131, 2024.
Article
de En
| MEDLINE
| ID: mdl-37749054
ABSTRACT
OBJECTIVE:
To elucidate particular placental pathology findings that are associated with hypoxic ischemic encephalopathy (HIE) and determine which patterns are associated with adverse fetal/neonatal outcomes. STUDYDESIGN:
Multi-institutional retrospective case-control study of newborns with HIE (2002-2022) and controls. Four perinatal pathologists performed gross and histologic evaluation of placentas of cases and controls.RESULTS:
A total of 265 placentas of neonates with HIE and 122 controls were examined. Infants with HIE were more likely to have anatomic umbilical cord abnormalities (19.7% vs 7.4%, P = .003), fetal inflammatory response in the setting of amniotic fluid infection (27.7% vs 13.9%, P = .004), and fetal vascular malperfusion (30.6% vs 9.0%, P = <.001) versus controls. Fetal vascular malperfusion with maternal vascular malperfusion was more common in those who died of disease (P = .01).CONCLUSION:
Placental pathology examination of neonates with HIE may improve our understanding of this disorder and its adverse outcomes.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies du placenta
/
Hypoxie-ischémie du cerveau
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
/
Infant
/
Newborn
/
Pregnancy
Langue:
En
Journal:
Pediatr Dev Pathol
Sujet du journal:
PATOLOGIA
/
PEDIATRIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique