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Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies.
Zendt, Mackenzie; Bustos Carrillo, Fausto A; Kelly, Sophie; Saturday, Taylor; DeGrange, Maureen; Ginigeme, Anita; Wu, Lurline; Callier, Viviane; Ortega-Villa, Ana; Faust, Mondreakest; Chang-Rabley, Emma; Bugal, Kara; Kenney, Heather; Khil, Pavel; Youn, Jung-Ho; Osei, Gloria; Regmi, Pravesh; Anderson, Victoria; Bosticardo, Marita; Daub, Janine; DiMaggio, Thomas; Kreuzburg, Samantha; Pala, Francesca; Pfister, Justina; Treat, Jennifer; Ulrick, Jean; Karkanitsa, Maria; Kalish, Heather; Kuhns, Douglas B; Priel, Debra L; Fink, Danielle L; Tsang, John S; Sparks, Rachel; Uzel, Gulbu; Waldman, Meryl A; Zerbe, Christa S; Delmonte, Ottavia M; Bergerson, Jenna R E; Das, Sanchita; Freeman, Alexandra F; Lionakis, Michail S; Sadtler, Kaitlyn; van Doremalen, Neeltje; Munster, Vincent; Notarangelo, Luigi D; Holland, Steven M; Ricotta, Emily E.
Affiliation
  • Zendt M; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Bustos Carrillo FA; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Kelly S; Office of Data Science and Emerging Technologies, Office of Science Management and Operations, NIAID, NIH, Rockville, MD, USA.
  • Saturday T; Trans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH, Bethesda, MD, USA.
  • DeGrange M; Laboratory of Virology, DIR, NIAID, NIH, Hamilton, NY, USA.
  • Ginigeme A; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Wu L; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Callier V; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Ortega-Villa A; Medical Science and Computing LLC, Rockville, MD, USA.
  • Faust M; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Chang-Rabley E; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Bugal K; Biostatistics Research Branch, Division of Clinical Research, NIAID, NIH, Rockville, MD, USA.
  • Kenney H; Section for Immunoengineering, NIBIB, NIH, Bethesda, MD, USA.
  • Khil P; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Youn JH; Division of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
  • Osei G; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Regmi P; Division of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
  • Anderson V; Division of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
  • Bosticardo M; Division of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
  • Daub J; Division of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
  • DiMaggio T; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Kreuzburg S; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Pala F; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Pfister J; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Treat J; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Ulrick J; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Karkanitsa M; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Kalish H; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Kuhns DB; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Priel DL; Section for Immunoengineering, NIBIB, NIH, Bethesda, MD, USA.
  • Fink DL; Trans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH, Bethesda, MD, USA.
  • Tsang JS; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Sparks R; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Uzel G; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Waldman MA; Department of Immunobiology and Yale Center for Systems and Engineering Immunology, Yale School of Medicine, New Haven, CT, USA.
  • Zerbe CS; Department of Biomedical Engineering, Yale University, New Haven, CT,USA.
  • Delmonte OM; Laboratory of Immune System Biology, DIR, NIAID, NIH, Bethesda, MD,USA.
  • Bergerson JRE; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Das S; Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
  • Freeman AF; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Lionakis MS; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Sadtler K; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • van Doremalen N; Division of Laboratory Medicine, NIH Clinical Center, Bethesda, MD,USA.
  • Munster V; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Holland SM; Section for Immunoengineering, NIBIB, NIH, Bethesda, MD, USA.
  • Ricotta EE; Laboratory of Virology, DIR, NIAID, NIH, Hamilton, NY, USA.
Sci Adv ; 9(41): eadh3150, 2023 10 13.
Article de En | MEDLINE | ID: mdl-37824621
ABSTRACT
Research on coronavirus disease 2019 vaccination in immune-deficient/disordered people (IDP) has focused on cancer and organ transplantation populations. In a prospective cohort of 195 IDP and 35 healthy volunteers (HV), antispike immunoglobulin G (IgG) was detected in 88% of IDP after dose 2, increasing to 93% by 6 months after dose 3. Despite high seroconversion, median IgG levels for IDP never surpassed one-third that of HV. IgG binding to Omicron BA.1 was lowest among variants. Angiotensin-converting enzyme 2 pseudo-neutralization only modestly correlated with antispike IgG concentration. IgG levels were not significantly altered by receipt of different messenger RNA-based vaccines, immunomodulating treatments, and prior severe acute respiratory syndrome coronavirus 2 infections. While our data show that three doses of coronavirus disease 2019 vaccinations induce antispike IgG in most IDP, additional doses are needed to increase protection. Because of the notably reduced IgG response to Omicron BA.1, the efficacy of additional vaccinations, including bivalent vaccines, should be studied in this population.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Immunoglobuline G / COVID-19 Limites: Humans Langue: En Journal: Sci Adv Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Immunoglobuline G / COVID-19 Limites: Humans Langue: En Journal: Sci Adv Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique