CEP20 promotes invasion and metastasis of non-small cell lung cancer cells by depolymerizing microtubules.
Sci Rep
; 13(1): 17484, 2023 10 14.
Article
de En
| MEDLINE
| ID: mdl-37838783
ABSTRACT
Worldwide, Lung cancer is the leading cause of cancer-related death and poses a direct health threat, non-small cell lung cancer (NSCLC) is the most common type. In this study, we demonstrated that centrosomal protein 20 (CEP20) is upregulated in NSCLC tissues and associated with cancer invasion metastasis. Notably, CEP20 depletion inhibited NSCLC cell proliferation, migration, and microtubule polymerization. Mechanistically, we discovered that CEP20 is critical in the development of NSCLC by regulating microtubule dynamics and cell adhesion-related signaling pathways. Furthermore, the knockdown or overexpression of CEP20 affects microtubule polymerization in A549 cell lines. Our research provides a promising therapeutic target for the diagnosis and treatment of lung cancer, as well as a theoretical and experimental basis for clinical application.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Carcinome pulmonaire non à petites cellules
/
MicroARN
/
Tumeurs du poumon
Limites:
Humans
Langue:
En
Journal:
Sci Rep
Année:
2023
Type de document:
Article
Pays d'affiliation:
Chine