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Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids.
Yasinska, Valentyna; Gómez, Cristina; Kolmert, Johan; Ericsson, Magnus; Pohanka, Anton; James, Anna; Andersson, Lars I; Sparreman-Mikus, Maria; Sousa, Ana R; Riley, John H; Bates, Stewart; Bakke, Per S; Zounemat Kermani, Nazanin; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J; Geiser, Thomas; Howarth, Peter H; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E; Knowles, Richard G; Dahlén, Barbro; Maitland-van der Zee, Anke-Hilse; Sterk, Peter J; Djukanovic, Ratko; Adcock, Ian M; Chung, Kian Fan; Wheelock, Craig E; Dahlén, Sven-Erik; Wikström Jonsson, Eva.
Affiliation
  • Yasinska V; Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  • Gómez C; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Kolmert J; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
  • Ericsson M; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Pohanka A; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
  • James A; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Andersson LI; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Sparreman-Mikus M; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
  • Sousa AR; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Riley JH; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Bates S; Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden.
  • Bakke PS; Laboratoire AntiDopage Français, Université Paris-Saclay, Châtenay-Malabry, France.
  • Zounemat Kermani N; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Caruso M; Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden.
  • Chanez P; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Fowler SJ; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
  • Geiser T; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Howarth PH; Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  • Horváth I; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Krug N; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
  • Montuschi P; Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
  • Sanak M; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden.
  • Behndig A; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.
  • Shaw DE; Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, UK.
  • Knowles RG; Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, UK.
  • Dahlén B; Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, UK.
  • Maitland-van der Zee AH; Institute of Clinical Science, University of Bergen, Bergen, Norway.
  • Sterk PJ; National Heart and Lung Institute and Data Science Institute, Imperial College London, London, UK.
  • Djukanovic R; Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
  • Adcock IM; Assistance Publique des Hôpitaux de Marseille, Clinique des Bronches, Allergies et Sommeil, Aix Marseille Université, Marseille, France.
  • Chung KF; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.
  • Wheelock CE; Manchester Academic Health Science Centre and NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
  • Dahlén SE; Department of Pulmonary Medicine, University Hospital, University of Bern, Bern, Switzerland.
  • Wikström Jonsson E; Faculty of Medicine, Southampton University, Southampton, UK.
ERJ Open Res ; 9(5)2023 Sep.
Article de En | MEDLINE | ID: mdl-37868143
ABSTRACT
Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure.

Methods:

Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry. Data were compared to that of mild-to-moderate asthmatics (MMA, n=70) and healthy subjects (HC, n=98) from the same study. Measurements and main

results:

The concentrations of urinary endogenous steroid metabolites were substantially lower in SA than in MMA or HC. These differences were more pronounced in SA patients with detectable urinary OCS metabolites. Their dehydroepiandrosterone sulfate (DHEA-S) concentrations were <5% of those in HC, and cortisol concentrations were below the detection limit in 75% of females and 82% of males. The concentrations of EAAS in OCS-positive patients, as well as patients on high-dose ICS only, were more suppressed in females than males (p<0.05). Low levels of DHEA were associated with features of more severe disease and were more prevalent in females (p<0.05). The association between low EAAS and corticosteroid treatment was replicated in 289 of the SA patients at follow-up after 12-18 months.

Conclusion:

The pronounced suppression of endogenous anabolic androgens in females might contribute to sex differences regarding the prevalence of severe asthma.

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: ERJ Open Res Année: 2023 Type de document: Article Pays d'affiliation: Suède

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: ERJ Open Res Année: 2023 Type de document: Article Pays d'affiliation: Suède