Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders.

Harrison, David; Billinton, Andy; Bock, Mark G; Doedens, John R; Gabel, Christopher A; Holloway, M Katharine; Porter, Roderick A; Reader, Valérie; Scanlon, Jane; Schooley, Kenneth; Watt, Alan P

Harrison, David; Billinton, Andy; Bock, Mark G; Doedens, John R; Gabel, Christopher A; Holloway, M Katharine; Porter, Roderick A; Reader, Valérie; Scanlon, Jane; Schooley, Kenneth; Watt, Alan P.

Affiliation

Harrison D; NodThera Ltd., Suite 8, The Mansion, Chesterford Research Park, Little Chesterford, Saffron Walden CB10 1XL, Essex, U.K.
Billinton A; NodThera Ltd., Suite 8, The Mansion, Chesterford Research Park, Little Chesterford, Saffron Walden CB10 1XL, Essex, U.K.
Bock MG; NodThera Inc., P.O. Box 156, Suite 1702, 265 Franklin Street, Boston, Massachusetts 02110, United States.
Doedens JR; NodThera Inc., 454 N 34th Street, Seattle, Washington 98103, United States.
Gabel CA; NodThera Inc., 454 N 34th Street, Seattle, Washington 98103, United States.
Holloway MK; Gfree Bio LLC, 5824 Brittlyns Ct, Austin, Texas 78730, United States.
Porter RA; Rod Porter Consultancy, 89 Back Street, Ashwell, Baldock SG7 5PG, Hertfordshire, U.K.
Reader V; NodThera Ltd., Suite 8, The Mansion, Chesterford Research Park, Little Chesterford, Saffron Walden CB10 1XL, Essex, U.K.
Scanlon J; NodThera Ltd., Suite 8, The Mansion, Chesterford Research Park, Little Chesterford, Saffron Walden CB10 1XL, Essex, U.K.
Schooley K; NodThera Inc., 454 N 34th Street, Seattle, Washington 98103, United States.
Watt AP; NodThera Ltd., Suite 8, The Mansion, Chesterford Research Park, Little Chesterford, Saffron Walden CB10 1XL, Essex, U.K.

J Med Chem ; 66(21): 14897-14911, 2023 11 09.

Article de En | MEDLINE | ID: mdl-37874905

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Inflammasomes / Protéine-3 de la famille des NLR contenant un domaine pyrine Limites: Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2023 Type de document: Article Pays d'affiliation: Royaume-Uni

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