Incidence and Bayesian Mapping of Myeloid Hematologic Malignancies in Sardinia, Italy.
Cancer Control
; 30: 10732748231202906, 2023.
Article
de En
| MEDLINE
| ID: mdl-37877513
ABSTRACT
BACKGROUND:
The epidemiology of myeloid hematologic malignancies in Italy has been poorly investigated.METHODS:
We used a validated database of 1974-2003 incident cases of hematologic malignancies among the resident population (all ages) of Sardinia, Italy, to describe the incidence of myeloid malignancies overall (N = 4389 cases) and by subtype. We investigated the time trend of acute myeloid leukemia (N = 1227 cases), chronic myeloid leukemia (N = 613 cases), and myelodysplastic syndrome (N = 1296 cases), and used Bayesian methods to explore their geographic spread, and Poisson regression analysis to estimate their association with environmental and socio-economic factors.RESULTS:
The annual standardized (world population) incidence rate (IR) of myeloid malignancies over the study period was 6.5 per 100,000 (95% CI 6.2-6.7). Myelodysplastic syndromes were the most prevalent subgroup (IR = 1.7, 95% CI 1.5-1.8). Incidence of all myeloid malignancies combined increased sharply during the study period with an annual percent change (APC) of 10.06% (95% CI 9.51-10.61), 19.77% for myelodysplastic syndromes (95% CI 19.63-19.91), and 3.18% (95% CI 2.99-3.37) for acute myeloid leukemia. Chronic myeloid leukemia did not show an upward trend. Apart from sporadic excesses in small rural communities and the major urban area, there was no evidence of spatial clustering. The risk of myeloid malignancies increased with increasing prevalence of sheep breeding.CONCLUSIONS:
Our results might prompt further research on the local genetic and environmental determinants of myeloid hematologic malignancies.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Syndromes myélodysplasiques
/
Leucémie myéloïde chronique BCR-ABL positive
/
Leucémie aigüe myéloïde
/
Tumeurs hématologiques
/
Syndromes myéloprolifératifs
Limites:
Animals
/
Humans
Langue:
En
Journal:
Cancer Control
Sujet du journal:
NEOPLASIAS
Année:
2023
Type de document:
Article
Pays d'affiliation:
Italie