A GPX4 non-enzymatic domain and MDM2 targeting peptide PROTAC for acute lymphoid leukemia therapy through ferroptosis induction.

Niu, Fan; Yang, Runyu; Feng, Hui; Liu, Yi; Liu, Ruimin; Ma, Bohan

Niu, Fan; Yang, Runyu; Feng, Hui; Liu, Yi; Liu, Ruimin; Ma, Bohan.

Affiliation

Niu F; Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yang R; Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Feng H; Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Liu Y; Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Liu R; Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ma B; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China. Electronic address: mabohan2009@sina.com.

Biochem Biophys Res Commun ; 684: 149125, 2023 12 03.

Article de En | MEDLINE | ID: mdl-37897912

Sujet(s)
Mots clés

ALL; Ferroptosis; GPX4; MDM2; PROTAC drug; Peptide drug

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Leucémie-lymphome lymphoblastique à précurseurs B et T / Ferroptose Limites: Humans Langue: En Journal: Biochem Biophys Res Commun Année: 2023 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique

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