Low serum creatinine as a prognostic marker in advanced cancer.
BMJ Support Palliat Care
; 2023 Oct 31.
Article
de En
| MEDLINE
| ID: mdl-37907252
ABSTRACT
OBJECTIVES:
To evaluate whether low serum creatinine levels are associated with poor outcomes in patients with advanced cancer.METHODS:
This is a secondary analysis of a prospective cohort study. Patients were divided into three groups according to their baseline serum creatinine levels. We performed time-to-event analyses using the Kaplan-Meier method and log-rank tests, and by conducting univariate and multivariate Cox regression analyses.RESULTS:
809 males were divided male-low group (n=192), male-normal group (n=403) and male-high group (n=214). 808 females were divided female-low group (n=239), female-normal group (n=389) and female-high group (n=180). Significant differences were observed in survival rates between the high and normal groups in the males and females (both log-rank p<0.001). Significantly higher risks of mortality were observed in the Cox proportional hazard model for the high group than for the normal group in both sexes (adjusted HR 1.292, 95% CI 1.082 to 1.542; adjusted HR 1.316, 95% CI 1.094 to 1.583, respectively). High serum creatinine was associated with shorter survival than normal creatinine, while low serum creatinine was not.CONCLUSIONS:
Low serum creatinine levels did not have prognostic abilities in this population.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
BMJ Support Palliat Care
Année:
2023
Type de document:
Article
Pays d'affiliation:
Japon