AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity.
Curr Opin Immunol
; 85: 102397, 2023 Dec.
Article
de En
| MEDLINE
| ID: mdl-37931499
ABSTRACT
The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription factors (TFs), including members of the activator protein (AP)-1 family. The activity of AP-1 family members is regulated by various immune signaling pathways, which can be triggered by activating or inhibitory receptors as well as cytokines. The target genes controlled by AP-1 TFs are central to generate immunity to pathogens or malignancies. Here, we provide an overview of the current understanding of how AP-1 TFs regulate cytotoxic lymphocytes.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs
/
Antinéoplasiques
Limites:
Humans
Langue:
En
Journal:
Curr Opin Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2023
Type de document:
Article
Pays d'affiliation:
Australie