Predicting pediatric cardiac surgery-associated acute kidney injury using machine learning.
Pediatr Nephrol
; 39(4): 1263-1270, 2024 Apr.
Article
de En
| MEDLINE
| ID: mdl-37934270
ABSTRACT
BACKGROUND:
Prediction of cardiac surgery-associated acute kidney injury (CS-AKI) in pediatric patients is crucial to improve outcomes and guide clinical decision-making. This study aimed to develop a supervised machine learning (ML) model for predicting moderate to severe CS-AKI at postoperative day 2 (POD2).METHODS:
This retrospective cohort study analyzed data from 402 pediatric patients who underwent cardiac surgery at a university-affiliated children's hospital, who were separated into an 80%-20% train-test split. The ML model utilized demographic, preoperative, intraoperative, and POD0 clinical and laboratory data to predict moderate to severe AKI categorized by Kidney Disease Improving Global Outcomes (KDIGO) stage 2 or 3 at POD2. Input feature importance was assessed by SHapley Additive exPlanations (SHAP) values. Model performance was evaluated using accuracy, area under the receiver operating curve (AUROC), precision, recall, area under the precision-recall curve (AUPRC), F1-score, and Brier score.RESULTS:
Overall, 13.7% of children in the test set experienced moderate to severe AKI. The ML model achieved promising performance, with accuracy of 0.91 (95% CI 0.82-1.00), AUROC of 0.88 (95% CI 0.72-1.00), precision of 0.92 (95% CI 0.70-1.00), recall of 0.63 (95% CI 0.32-0.96), AUPRC of 0.81 (95% CI 0.61-1.00), F1-score of 0.73 (95% CI 0.46-0.99), and Brier score loss of 0.09 (95% CI 0.00-0.17). The top ten most important features assessed by SHAP analyses in this model were preoperative serum creatinine, surgery duration, POD0 serum pH, POD0 lactate, cardiopulmonary bypass duration, POD0 vasoactive inotropic score, sex, POD0 hematocrit, preoperative weight, and POD0 serum creatinine.CONCLUSIONS:
A supervised ML model utilizing demographic, preoperative, intraoperative, and immediate postoperative clinical and laboratory data showed promising performance in predicting moderate to severe CS-AKI at POD2 in pediatric patients.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Atteinte rénale aigüe
/
Procédures de chirurgie cardiaque
Limites:
Child
/
Humans
Langue:
En
Journal:
Pediatr Nephrol
Sujet du journal:
NEFROLOGIA
/
PEDIATRIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique