Tackling seizures in patients with Alzheimer's disease.
Expert Rev Neurother
; 23(12): 1131-1145, 2023.
Article
de En
| MEDLINE
| ID: mdl-37946507
ABSTRACT
INTRODUCTION:
In past years, a possible bidirectional link between epilepsy and Alzheimer's disease (AD) has been proposed if AD patients are more likely to develop epilepsy, people with late-onset epilepsy evidence an increased risk of dementia. Furthermore, current research suggested that subclinical epileptiform discharges may be more frequent in patients with AD and network hyperexcitability may hasten cognitive impairment. AREAS COVERED In this narrative review, the authors discuss the recent evidence linking AD and epilepsy as well as seizures semeiology and epileptiform activity observed in patients with AD. Finally, anti-seizure medications (ASMs) and therapeutic trials to tackle seizures and network hyperexcitability in this clinical scenario have been summarized. EXPERT OPINION There is growing experimental evidence demonstrating a strong connection between seizures, neuronal hyperexcitability, and AD. Epilepsy in AD has shown a good response to ASMs both at the late and prodromal stages. The new generation ASMs with fewer cognitive adverse effects seem to be a preferable option. Data on the possible effects of network hyperexcitability and ASMs on AD progression are still inconclusive. Further clinical trials are mandatory to identify clear guidelines about treatment of subclinical epileptiform discharges in patients with AD without seizures.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Épilepsie
/
Maladie d'Alzheimer
/
Dysfonctionnement cognitif
Limites:
Humans
Langue:
En
Journal:
Expert Rev Neurother
Sujet du journal:
NEUROLOGIA
/
TERAPEUTICA
Année:
2023
Type de document:
Article
Pays d'affiliation:
Italie