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The CXCL10-CXCR3 axis plays an important role in Kawasaki disease.
Hosaka, Sho; Imagawa, Kazuo; Yano, Yusuke; Lin, Lisheng; Shiono, Junko; Takahashi-Igari, Miho; Hara, Hideki; Hayashi, Daisuke; Imai, Hironori; Morita, Atsushi; Fukushima, Hiroko; Takada, Hidetoshi.
Affiliation
  • Hosaka S; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.
  • Imagawa K; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.
  • Yano Y; Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan.
  • Lin L; Department of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.
  • Shiono J; Department of Pediatric Cardiology, Ibaraki Children's Hospital, Mito City, Japan.
  • Takahashi-Igari M; Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan.
  • Hara H; Department of Pediatric Cardiology, Ibaraki Children's Hospital, Mito City, Japan.
  • Hayashi D; Department of Pediatric Cardiology, Ibaraki Children's Hospital, Mito City, Japan.
  • Imai H; Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan.
  • Morita A; Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan.
  • Fukushima H; Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan.
  • Takada H; Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan.
Clin Exp Immunol ; 216(1): 104-111, 2024 03 12.
Article de En | MEDLINE | ID: mdl-37952216
ABSTRACT
The precise pathogenesis of Kawasaki disease remains unknown. In an attempt to elucidate the pathogenesis of KD through the analysis of acquired immunity, we comprehensively examined the immunophenotypic changes in immune cells such as lymphocytes and monocytes along with various cytokines, focusing on differences between pre- and post- treatment samples. We found high levels of CXCL9 and CXCL10 chemokines that decreased with treatment, which coincided with a post-treatment expansion of Th1 cells expressing CXCR3. Our results show that the CXCL10-CXCR3 axis plays an important role in the pathogenesis of KD.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie de Kawasaki Limites: Humans Langue: En Journal: Clin Exp Immunol Année: 2024 Type de document: Article Pays d'affiliation: Japon
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie de Kawasaki Limites: Humans Langue: En Journal: Clin Exp Immunol Année: 2024 Type de document: Article Pays d'affiliation: Japon