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Engineered organoids for biomedical applications.
Roberto de Barros, Natan; Wang, Canran; Maity, Surjendu; Peirsman, Arne; Nasiri, Rohollah; Herland, Anna; Ermis, Menekse; Kawakita, Satoru; Gregatti Carvalho, Bruna; Hosseinzadeh Kouchehbaghi, Negar; Donizetti Herculano, Rondinelli; Tirpáková, Zuzana; Mohammad Hossein Dabiri, Seyed; Lucas Tanaka, Jean; Falcone, Natashya; Choroomi, Auveen; Chen, RunRun; Huang, Shuyi; Zisblatt, Elisheva; Huang, Yixuan; Rashad, Ahmad; Khorsandi, Danial; Gangrade, Ankit; Voskanian, Leon; Zhu, Yangzhi; Li, Bingbing; Akbari, Mohsen; Lee, Junmin; Remzi Dokmeci, Mehmet; Kim, Han-Jun; Khademhosseini, Ali.
Affiliation
  • Roberto de Barros N; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA. Electronic address: nbarros@terasaki.org.
  • Wang C; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA.
  • Maity S; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Peirsman A; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Plastic and Reconstructive Surgery, Ghent University Hospital, Ghent, Belgium.
  • Nasiri R; Division of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, 17165 Solna, Sweden.
  • Herland A; Division of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, 17165 Solna, Sweden.
  • Ermis M; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Kawakita S; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Gregatti Carvalho B; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Department of Material and Bioprocess Engineering, School of Chemical Engineering, University of Campinas (UNICAMP), 13083-970 Campinas, Brazil.
  • Hosseinzadeh Kouchehbaghi N; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Department of Textile Engineering, Amirkabir University of Technology (Tehran Polytechnic), Hafez Avenue, 1591634311 Tehran, Iran.
  • Donizetti Herculano R; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Autonomy Research Center for STEAHM (ARCS), California State University, Northridge, CA 91324, USA; São Paulo State University (UNESP), Bioengineering and Biomaterials Group, School of Pharmaceutical Sciences, Araraquar
  • Tirpáková Z; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 04181 Kosice, Slovakia.
  • Mohammad Hossein Dabiri S; Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
  • Lucas Tanaka J; Butantan Institute, Viral Biotechnology Laboratory, São Paulo, SP Brazil; University of São Paulo (USP), São Paulo, SP Brazil.
  • Falcone N; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Choroomi A; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Chen R; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Autonomy Research Center for STEAHM (ARCS), California State University, Northridge, CA 91324, USA.
  • Huang S; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Autonomy Research Center for STEAHM (ARCS), California State University, Northridge, CA 91324, USA.
  • Zisblatt E; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Huang Y; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Rashad A; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Khorsandi D; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Gangrade A; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Voskanian L; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Zhu Y; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Li B; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Autonomy Research Center for STEAHM (ARCS), California State University, Northridge, CA 91324, USA.
  • Akbari M; Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
  • Lee J; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Remzi Dokmeci M; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
  • Kim HJ; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; College of Pharmacy, Korea University, Sejong 30019, Republic of Korea. Electronic address: hanjun@korea.ac.kr.
  • Khademhosseini A; Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA. Electronic address: khademh@terasaki.org.
Adv Drug Deliv Rev ; 203: 115142, 2023 12.
Article de En | MEDLINE | ID: mdl-37967768
ABSTRACT
As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are rapidly emerging as powerful tools for biomedical applications. With their potential for personalized therapeutic interventions and high-throughput drug screening, organoids have gained significant attention recently. In this review, we discuss the latest developments in engineering organoids and using materials engineering, biochemical modifications, and advanced manufacturing technologies to improve organoid culture and replicate vital anatomical structures and functions of human tissues. We then explore the diverse biomedical applications of organoids, including drug development and disease modeling, and highlight the tools and analytical techniques used to investigate organoids and their microenvironments. We also examine the latest clinical trials and patents related to organoids that show promise for future clinical translation. Finally, we discuss the challenges and future perspectives of using organoids to advance biomedical research and potentially transform personalized medicine.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Organoïdes / Recherche biomédicale Limites: Humans Langue: En Journal: Adv Drug Deliv Rev Sujet du journal: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Année: 2023 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Organoïdes / Recherche biomédicale Limites: Humans Langue: En Journal: Adv Drug Deliv Rev Sujet du journal: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Année: 2023 Type de document: Article