Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA.
Expert Opin Ther Targets
; 27(11): 1159-1172, 2023.
Article
de En
| MEDLINE
| ID: mdl-37971192
ABSTRACT
INTRODUCTION:
Recent neuroscience breakthroughs have shed light on the sophisticated relationship between calcium channelopathies and movement disorders, exposing a previously undiscovered tale focusing on the Ryanodine Receptor (RyR) and the Sarco/Endoplasmic Reticulum Calcium ATPase (SERCA). Calcium signaling mainly orchestrates neural communication, which regulates synaptic transmission and total network activity. It has been determined that RyR play a significant role in managing neuronal functions, most notably in releasing intracellular calcium from the endoplasmic reticulum. AREAS COVERED It highlights the involvement of calcium channels such as RyR and SERCA in physiological and pathophysiological conditions. EXPERT OPINION Links between RyR and SERCA activity dysregulation, aberrant calcium levels, motor and cognitive dysfunction have brought attention to the importance of RyR and SERCA modulation in neurodegenerative disorders. Understanding the obscure function of these proteins will open up new therapeutic possibilities to address the underlying causes of neurodegenerative diseases. The unreported RyR and SERCA narrative broadens the understanding of calcium channelopathies in movement disorders and calls for more research into cutting-edge therapeutic approaches.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies neurodégénératives
/
Canalopathies
/
Troubles de la motricité
Limites:
Humans
Langue:
En
Journal:
Expert Opin Ther Targets
Sujet du journal:
TERAPEUTICA
Année:
2023
Type de document:
Article
Pays d'affiliation:
Inde