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Curcumin Mitigates Malathion-Induced Renal Injury: Suppression of Apoptosis and Modulation of NF-κß/TNF-α and Nrf2, and HO-1 Signaling.
Eldesoqui, Mamdouh; Ahmed, Magda E; Abdel-Kareem, Mona A; Badawy, Mohamed Moharram; Dawood, Amal Fahmy; Mohamed, Abdelaty Shawky; Ibrahim, Ateya Megahed; El-Mansi, Ahmed A; El-Sherbiny, Mohamad; Hendawy, Mahmoud.
Affiliation
  • Eldesoqui M; Department of Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
  • Ahmed ME; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia.
  • Abdel-Kareem MA; Department of Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
  • Badawy MM; Department of Anatomy and Embryology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh P.O. Box 33516, Egypt.
  • Dawood AF; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
  • Mohamed AS; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Delta University for Science and Technology, Gamasa 11152, Egypt.
  • Ibrahim AM; Department of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
  • El-Mansi AA; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia.
  • El-Sherbiny M; Pathology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
  • Hendawy M; Department of Nursing, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Metabolites ; 13(11)2023 Oct 30.
Article de En | MEDLINE | ID: mdl-37999213
Malathion is one of the most used organophosphorus pesticides that is used for many reasons such as agriculture and industry. Human exposure to malathion may occur through various means, such as eating food that has been treated with it. Malathion not only increases oxidative stress but also decreases the antioxidant capacity. Curcumin is a powerful antioxidant with many pharmacological actions. Curcumin can act as a free radical scavenger and inhibit the activation and nuclear translocation of NF-κB. Curcumin could combat the lipid peroxidation and antioxidant depletion that trigger the apoptotic pathways. This study aims to examine the antioxidant, anti-inflammatory, and antiapoptotic effects of curcumin. Twenty-four Sprague Dawley rats were divided into four groups (six rats each): control, curcumin, malathion, and malathion + curcumin groups. At the assigned time, blood samples were used for the assessment of serum creatinine, and the kidneys were excised and washed; parts of them were used for the assessment of total oxidant status (TOS), oxidative stress index (OSI), the oxidative stress marker malondialdehyde (MDA), total antioxidant capacity (TAC), and glutathione (GSH) activity, other parts were fixed in formalin for further staining. Histopathological evaluation was performed for the fixed specimens after staining with H&E, sirus red, and the immunohistochemical staining for NF-κß, TNF-α, Caspase-3, Nrf2, and HO-1. Curcumin significantly decreases the serum creatinine after malathion exposure and significantly restores the oxidant/antioxidant balance by increasing TAC and GSH and decreasing TOS, OSI, and MDA. Curcumin exerts its reno-protective effect and restores the histological architecture of the kidney by downregulating the immune expression of NF-κß, TNF-α, and Caspase-3 and upregulating the expression of Nrf2 and HO-1. This study concluded that curcumin protects against nephrotoxicity caused by malathion by exerting its antioxidant, anti-inflammatory, and anti-apoptotic capabilities.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Metabolites Année: 2023 Type de document: Article Pays d'affiliation: Égypte Pays de publication: Suisse

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Metabolites Année: 2023 Type de document: Article Pays d'affiliation: Égypte Pays de publication: Suisse