Cellular senescence in brain aging and neurodegeneration.
Ageing Res Rev
; 93: 102141, 2024 Jan.
Article
de En
| MEDLINE
| ID: mdl-38030088
ABSTRACT
Cellular senescence is a state of terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells naturally accumulate during aging and at sites of age-related pathologies. Here, we discuss the recent advances in understanding the accumulation of senescent cells in brain aging and disorders. Here we highlight the phenotypical heterogeneity of different senescent brain cell types, highlighting the potential importance of subtype-specific features for physiology and pathology. We provide a comprehensive overview of various senescent cell types in naturally occurring aging and the most common neurodegenerative disorders. Finally, we critically discuss the potential of adapting senotherapeutics to improve brain health and reduce pathological progression, addressing limitations and future directions for application and development.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vieillissement
/
Maladies neurodégénératives
Limites:
Humans
Langue:
En
Journal:
Ageing Res Rev
Sujet du journal:
GERIATRIA
Année:
2024
Type de document:
Article