Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants.

Korenkov, Michael; Zehner, Matthias; Cohen-Dvashi, Hadas; Borenstein-Katz, Aliza; Kottege, Lisa; Janicki, Hanna; Vanshylla, Kanika; Weber, Timm; Gruell, Henning; Koch, Manuel; Diskin, Ron; Kreer, Christoph; Klein, Florian

Korenkov, Michael; Zehner, Matthias; Cohen-Dvashi, Hadas; Borenstein-Katz, Aliza; Kottege, Lisa; Janicki, Hanna; Vanshylla, Kanika; Weber, Timm; Gruell, Henning; Koch, Manuel; Diskin, Ron; Kreer, Christoph; Klein, Florian.

Affiliation

Korenkov M; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Zehner M; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Cohen-Dvashi H; Department of Chemical and Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Borenstein-Katz A; Department of Chemical and Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Kottege L; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Janicki H; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Vanshylla K; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Weber T; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Gruell H; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Koch M; Institute for Dental Research and Oral Musculoskeletal Biology and Center for Biochemistry, University of Cologne, 50931 Cologne, Germany.
Diskin R; Department of Chemical and Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Kreer C; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany. Electronic address: christoph.kreer@uk-koeln.de.
Klein F; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany; German Center for Infection Research, Partner Site Bonn-Cologne, 50931 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), Uni

Immunity ; 56(12): 2803-2815.e6, 2023 Dec 12.

Article de En | MEDLINE | ID: mdl-38035879

Sujet(s)
Mots clés

B cell receptor; SARS-CoV-2; SHM; antibody; bystander mutation; germline; imprinting; mutation; somatic hypermutation; viral escape

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: SARS-CoV-2 / COVID-19 Limites: Humans Langue: En Journal: Immunity Sujet du journal: ALERGIA E IMUNOLOGIA Année: 2023 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: États-Unis d'Amérique

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