Enzymatic prodrug degradation in the fasted and fed small intestine: In vitro studies and interindividual variability in human aspirates.

Vinarov, Zahari; Tistaert, Christophe; Bevernage, Jan; Bohets, Hugo; Augustijns, Patrick

Vinarov, Zahari; Tistaert, Christophe; Bevernage, Jan; Bohets, Hugo; Augustijns, Patrick.

Affiliation

Vinarov Z; Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; Department of Chemical and Pharmaceutical Engineering, Faculty of Chemistry and Pharmacy, Sofia University.
Tistaert C; Pharmaceutical Sciences, Janssen Research & Development, Beerse, Belgium.
Bevernage J; Pharmaceutical Sciences, Janssen Research & Development, Beerse, Belgium.
Bohets H; Pharmaceutical Sciences, Janssen Research & Development, Beerse, Belgium.
Augustijns P; Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. Electronic address: Patrick.augustijns@kuleuven.be.

Int J Pharm ; 649: 123654, 2024 Jan 05.

Article de En | MEDLINE | ID: mdl-38036195

Sujet(s)
Mots clés

Drug stability; Ester hydrolysis; Human intestinal fluids; Prodrug

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Promédicaments Limites: Humans Langue: En Journal: Int J Pharm Année: 2024 Type de document: Article Pays de publication: Pays-Bas

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