Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence.

Kochan, Travis J; Nozick, Sophia H; Valdes, Aliki; Mitra, Sumitra D; Cheung, Bettina H; Lebrun-Corbin, Marine; Medernach, Rachel L; Vessely, Madeleine B; Mills, Jori O; Axline, Christopher M R; Nelson, Julia A; VanGosen, Ethan M; Ward, Timothy J; Ozer, Egon A; van Duin, David; Chen, Liang; Kreiswirth, Barry N; Long, S Wesley; Musser, James M; Bulman, Zackery P; Wunderink, Richard G; Hauser, Alan R

Kochan, Travis J; Nozick, Sophia H; Valdes, Aliki; Mitra, Sumitra D; Cheung, Bettina H; Lebrun-Corbin, Marine; Medernach, Rachel L; Vessely, Madeleine B; Mills, Jori O; Axline, Christopher M R; Nelson, Julia A; VanGosen, Ethan M; Ward, Timothy J; Ozer, Egon A; van Duin, David; Chen, Liang; Kreiswirth, Barry N; Long, S Wesley; Musser, James M; Bulman, Zackery P; Wunderink, Richard G; Hauser, Alan R.

Affiliation

Kochan TJ; Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Travis.Kochan@fda.hhs.gov.
Nozick SH; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Travis.Kochan@fda.hhs.gov.
Valdes A; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Mitra SD; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Cheung BH; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lebrun-Corbin M; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Medernach RL; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Vessely MB; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Mills JO; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Axline CMR; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Nelson JA; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
VanGosen EM; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ward TJ; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ozer EA; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
van Duin D; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Chen L; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kreiswirth BN; Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Long SW; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Musser JM; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Bulman ZP; Department of Pathology and Genomic Medicine, Houston Methodist Hospital Research Institute, Houston, TX, USA.
Wunderink RG; Department of Pathology and Genomic Medicine, Houston Methodist Hospital Research Institute, Houston, TX, USA.
Hauser AR; College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.

Nat Commun ; 14(1): 7962, 2023 Dec 02.

Article de En | MEDLINE | ID: mdl-38042959

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Facteurs de virulence / Klebsiella pneumoniae Limites: Animals / Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

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