Hypertonic sodium chloride solutions: effect on hemodynamics and survival after hemorrhage in swine.
J Trauma
; 27(1): 32-9, 1987 Jan.
Article
de En
| MEDLINE
| ID: mdl-3806709
ABSTRACT
We evaluated the hemodynamic response of 12% shed blood replacement with 7.5% sodium chloride after a nonlethal hemorrhage in chronically instrumented swine. Compared to no treatment or Ringer's lactate infusion, the hypertonic salt solution was followed by increased cardiac output. We then evaluated the effect of hypertonic sodium chloride on survival after an otherwise lethal hemorrhage in chronically instrumented and unanesthetized swine. Survival was significantly greater after replacement of 25% of the shed blood with 7.5%, but not with 0.9%, 5.0%, or 10.0% sodium chloride solution. The mechanism appears to be by increased tissue perfusion as indicated by lower lactate values. Resuscitation with low-volume hypertonic sodium chloride may be life saving and life supporting during the initial treatment of trauma patients when conventional therapy is not available.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Réanimation
/
Solution saline hypertonique
/
Choc hémorragique
/
Chlorure de sodium
/
Traitement par apport liquidien
/
Hémodynamique
Limites:
Animals
Langue:
En
Journal:
J Trauma
Année:
1987
Type de document:
Article