Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol.
Photodiagnosis Photodyn Ther
; 45: 103930, 2024 Feb.
Article
de En
| MEDLINE
| ID: mdl-38103584
ABSTRACT
SIGNIFICANCE:
Evaluate a photodynamic therapy (PDT) protocol for low-risk basal cell carcinoma (BCC) treatment that requires less time spent at the hospital and is less painful.APPROACH:
Eight BCCs were selected, debulked, and received 20 % methyl aminolevulinate cream. After 3 h, the first irradiation was performed at the hospital (20 min, 150 J/cm2). Then, the cream was re-applied, and a portable irradiation prototype was fixed to the skin around the lesion. After 1.5 h, the patients turned on the prototype for irradiation at home (for 2 h, totalizing 312 J/cm2). Disease-free survival rate and pain score during irradiations were evaluated.RESULTS:
The clearance at 30 days after PDT was 87.5 % by histological analysis. The mean follow-up was 21.5 months and the recurrence-free survival at 22 months was 75 %. The pain score was significantly lower at home.CONCLUSIONS:
A potentially less painful and more comfortable PDT treatment protocol with proven long-term efficiency is presented. A randomized clinical trial has been conducted to confirm these results.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Photothérapie dynamique
/
Tumeurs cutanées
/
Carcinome basocellulaire
Limites:
Humans
Langue:
En
Journal:
Photodiagnosis Photodyn Ther
Sujet du journal:
DIAGNOSTICO POR IMAGEM
/
TERAPEUTICA
Année:
2024
Type de document:
Article
Pays de publication:
Pays-Bas