Clinical utility of procalcitonin in implementation of procalcitonin-guided antibiotic stewardship in the South-East Asia and India: evidence and consensus-based recommendations.
Expert Rev Anti Infect Ther
; 22(1-3): 45-58, 2024.
Article
de En
| MEDLINE
| ID: mdl-38112181
ABSTRACT
INTRODUCTION:
The South-East Asian (SEA) region and India are highly susceptible to antibiotic resistance, which is caused due to lack of antimicrobial stewardship (AMS) knowledge, uncontrolled use of antibiotics, and poor infection control. Nonadherence to national/local guidelines, developed to combat antimicrobial resistance, is a major concern. A virtual advisory board was conducted to understand the current AMS standards and challenges in its implementation in these regions. AREAS COVERED Procalcitonin (PCT)-guided antibiotic use was discussed in various clinical conditions across initiation, management, and discontinuation stages. Most experts strongly recommended using PCT-driven antibiotic therapy among patients with lower respiratory tract infections, sepsis, and COVID-19. However, additional research is required to understand the optimal use of PCT in patients with organ transplantation and cancer patients with febrile neutropenia. Implementation of the solutions discussed in this review can help improve PCT utilization in guiding AMS in these regions and reducing challenges. EXPERT OPINION Experts strongly support the inclusion of PCT in AMS. They believe that PCT in combination with other clinical data to guide antibiotic therapy may result in more personalized and precise targeted antibiotic treatment. The future of PCT in antibiotic treatment is promising and may result in effective utilization of this biomarker.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sepsie
/
Gestion responsable des antimicrobiens
Limites:
Humans
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Expert Rev Anti Infect Ther
/
Expert rev. ant. infect. ther
/
Expert review of anti-infective therapy
Sujet du journal:
DOENCAS TRANSMISSIVEIS
Année:
2024
Type de document:
Article
Pays d'affiliation:
Singapour
Pays de publication:
Royaume-Uni