Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders.
Neuroimage Clin
; 41: 103554, 2024.
Article
de En
| MEDLINE
| ID: mdl-38128160
ABSTRACT
INTRODUCTION:
Although comorbidity of post-traumatic stress disorder (PTSD) with borderline personality disorder (BPD) and/or cluster C personality disorders (CPD) is common, neural correlates of this comorbidity are unknown.METHODS:
We acquired functional MRI scans during an emotional face task in participants with PTSD + CPD (n = 34), PTSD + BPD (n = 24), PTSD + BPD + CPD (n = 18) and controls (n = 30). We used ANCOVAs and Bayesian analyses on specific ROIs in a fearful vs. scrambled faces contrast. We also investigated associations with clinical measures.RESULTS:
There were no robust differences in brain activation between the groups with ANCOVAs. Transdiagnostically, we found a negative association between severity of dissociation and right insula and right dmPFC activation, and emotion regulation problems with right dmPFC activation. Bayesian analyses showed credible evidence for higher activation in all ROIs in the PTSD + BPD + CPD group compared to PTSD + BPD and PTSD + CPD.DISCUSSION:
Our Bayesian and correlation analyses support new dimensional conceptualizations of personality disorders.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Troubles de stress post-traumatique
/
Trouble de la personnalité limite
Limites:
Humans
Langue:
En
Journal:
Neuroimage Clin
Année:
2024
Type de document:
Article