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Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G.
Simunic-Briski, Nina; Dukaric, Vedran; Ocic, Mateja; Madzar, Tomislav; Vinicki, Martina; Frkatovic-Hodzic, Azra; Knjaz, Damir; Lauc, Gordan.
Affiliation
  • Simunic-Briski N; Genos Ltd, 10000, Zagreb, Croatia.
  • Dukaric V; Faculty of Kinesiology, University of Zagreb, 10000, Zagreb, Croatia.
  • Ocic M; Faculty of Kinesiology, University of Zagreb, 10000, Zagreb, Croatia.
  • Madzar T; Vas Pregled Sports and Occupation Medicine Polyclinic, 10000, Zagreb, Croatia.
  • Vinicki M; University of Applied Health Sciences, 10000, Zagreb, Croatia.
  • Frkatovic-Hodzic A; Genos Ltd, 10000, Zagreb, Croatia.
  • Knjaz D; Genos Ltd, 10000, Zagreb, Croatia.
  • Lauc G; Faculty of Kinesiology, University of Zagreb, 10000, Zagreb, Croatia.
Glycoconj J ; 41(1): 67-76, 2024 02.
Article de En | MEDLINE | ID: mdl-38147152
ABSTRACT
Physical inactivity and obesity are growing concerns, negatively impacting the general population. Moderate physical activity is known to have a beneficial anti-inflammatory effect. N-glycosylation of immunoglobulin G (IgG) reflects changes in the inflammatory potential of IgG. In this study, GlycanAge index of biological age (GlycanAge), one of the first commercially used biomarkers of aging, was employed to assess effects of exercise intensity in three different groups of athletes professional competing athletes, regularly moderate active individuals and newly involved recreational individuals, compared to the group of inactive individuals. GlycanAge was significantly lower in the active group compared to the inactive group (ß = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (ß = 7.546, p = 3.20E-02). Competing female athletes had significantly higher GlycanAge comparing to active females exercising moderately (ß = 20.206, p.adj = 2.71E-02), while the latter had significantly lower GlycanAge when compared with the inactive counterparts (ß = -9.762, p.adj = 4.68E-02). Regular, life-long moderate exercise has an anti-inflammatory effect in both female and male population, demonstrated by lower GlycanAge index, and it has great potential to mitigate growing issues related to obesity and a sedentary lifestyle, which are relentlessly increasing world-wide.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Immunoglobuline G / Exercice physique Limites: Female / Humans / Male Langue: En Journal: Glycoconj J Sujet du journal: BIOQUIMICA / METABOLISMO Année: 2024 Type de document: Article Pays d'affiliation: Croatie

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Immunoglobuline G / Exercice physique Limites: Female / Humans / Male Langue: En Journal: Glycoconj J Sujet du journal: BIOQUIMICA / METABOLISMO Année: 2024 Type de document: Article Pays d'affiliation: Croatie