Streamlined Arsenolipid Identification via Direct Arsenic Detection Using RPLC-ESI-QTOF-MS with Collision-Induced Dissociation.
J Am Soc Mass Spectrom
; 35(2): 300-306, 2024 Feb 07.
Article
de En
| MEDLINE
| ID: mdl-38147679
ABSTRACT
Arsenolipids are organoarsenicals with a long aliphatic chain that have been identified in a wide array of marine organisms. Precise analysis of arsenolipids is crucial for evaluating their toxicity, ensuring food safety, monitoring the environment, and gaining insights into the evolution of arsenic biogeochemistry. However, the discovery of new arsenolipids is often impeded by existing analytical challenges, notably the need for multiple instruments, such as the combination of liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS) and inductively coupled plasma mass spectrometry (LC-ICP-MS). This study introduces a high-throughput untargeted analytical method on the basis of an unsophisticated instrumental configuration, LC-ESI-MS with collision-induced dissociation (CID) at 200 eV. This approach provides efficient dissociation of arsenic atoms from their precursor lipids and direct detection of the organic-bound arsenic as monatomic cations, As+. Application of this method has shown promise in rapidly characterizing arsenolipids in diverse samples, which has led to the discovery of a wide range of novel arsenolipids, including seven previously unidentified thioxoarsenolipids in ancient marine sediments.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Arsenic
/
Composés de l'arsenic
Langue:
En
Journal:
J Am Soc Mass Spectrom
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique