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Sex-Specific Acute Cerebrovascular Responses to Photothrombotic Stroke in Mice.
Raman-Nair, Joanna; Cron, Gregory; MacLeod, Kathleen; Lacoste, Baptiste.
Affiliation
  • Raman-Nair J; Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6, Canada.
  • Cron G; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
  • MacLeod K; Neurology Department, Stanford University, Stanford 94305, California.
  • Lacoste B; Pharmaceutical Sciences, University of British Colombia, Vancouver V6T 1Z3, British Columbia, Canada.
eNeuro ; 11(1)2024 Jan.
Article de En | MEDLINE | ID: mdl-38164600
ABSTRACT
Mechanisms underlying cerebrovascular stroke outcomes are poorly understood, and the effects of biological sex on cerebrovascular regulation post-stroke have yet to be fully comprehended. Here, we explore the overlapping roles of gonadal sex hormones and rho-kinase (ROCK), two important modulators of cerebrovascular tone, on the acute cerebrovascular response to photothrombotic (PT) focal ischemia in mice. Male mice were gonadectomized and female mice were ovariectomized to remove gonadal hormones, whereas control ("intact") animals received a sham surgery prior to stroke induction. Intact wild-type (WT) males showed a delayed drop in cerebral blood flow (CBF) compared with intact WT females, whereby maximal CBF drop was observed 48 h following stroke. Gonadectomy in males did not alter this response. However, ovariectomy in WT females produced a "male-like" phenotype. Intact Rock2+/- males also showed the same phenotypic response, which was not altered by gonadectomy. Alternatively, intact Rock2+/- females showed a significant difference in CBF values compared with intact WT females, displaying higher CBF values immediately post-stroke and showing a maximal CBF drop 48 h post-stroke. This pattern was not altered by ovariectomy. Altogether, these data illustrate sex differences in acute CBF responses to PT stroke, which seem to involve gonadal female sex hormones and ROCK2. Overall, this study provides a framework for exploring sex differences in acute CBF responses to focal ischemic stroke in mice.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Hormones sexuelles stéroïdiennes / Accident vasculaire cérébral Limites: Animals / Female / Humans / Male Langue: En Journal: ENeuro / ENeuro Année: 2024 Type de document: Article Pays d'affiliation: Canada Pays de publication: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Hormones sexuelles stéroïdiennes / Accident vasculaire cérébral Limites: Animals / Female / Humans / Male Langue: En Journal: ENeuro / ENeuro Année: 2024 Type de document: Article Pays d'affiliation: Canada Pays de publication: États-Unis d'Amérique