Lower-Body Fractures and the Risk of Dementia: A Nationwide Population-Based Study.
J Clin Neurol
; 20(2): 208-213, 2024 Mar.
Article
de En
| MEDLINE
| ID: mdl-38171503
ABSTRACT
BACKGROUND AND PURPOSE:
The association between physical activity and dementia has been shown in various observational studies. We aimed to determine the risk of dementia in the elderly with lower-body fractures.METHODS:
We reconstructed a population-based matched cohort from the National Health Insurance Service-Senior Cohort data set that covers 511,953 recipients of medical insurance in South Korea.RESULTS:
Overall 53,776 subjects with lower-body fractures were identified during 2006-2012, and triplicate control groups were matched randomly by sex, age, and years from the index date for each subject with a fracture. There were 3,573 subjects (6.6%) with and 7,987 subjects (4.9%) without lower-body fractures who developed dementia from 2008 up to 2015. Lower-body fractures were independently associated with a subsequent dementia diagnosis with a higher adjusted hazard ratio (aHR) (1.55, 95% confidence interval [CI]=1.49-1.62) compared with upper-body fractures (aHR=1.19, 95% CI=1.14-1.23).CONCLUSIONS:
These results support the protective role of physical activity against dementia and highlight the importance of promoting fracture prevention in the elderly.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Type d'étude:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Langue:
En
Journal:
J Clin Neurol
Année:
2024
Type de document:
Article
Pays de publication: