Clinical Impact of Improvement in Sarcopenia through Cardiac Rehabilitation in Patients with Heart Failure.
J Am Med Dir Assoc
; 25(3): 514-520.e2, 2024 Mar.
Article
de En
| MEDLINE
| ID: mdl-38182121
ABSTRACT
OBJECTIVES:
Sarcopenia in patients with heart failure (HF) is associated with poor prognosis. Cardiac rehabilitation (CR) decreases the incidence of adverse events in patients with HF. However, the clinical implications of improving sarcopenia status through CR remain unclear. This study investigated the relationship between the changes in sarcopenia status in patients with HF undergoing outpatient CR and the risk of mortality and adverse events.DESIGN:
This was a retrospective cohort study of patients hospitalized at the Kitasato University Hospital Cardiovascular Center for the treatment of HF between January 2007 and December 2020. SETTING ANDPARTICIPANTS:
Patients with HF whose sarcopenia status was assessed at hospital discharge and following at least 3 months of outpatient CR were included. Based on the sarcopenia status, all patients were divided into 3 groups patients without sarcopenia at discharge (ie, robust), patients with sarcopenia at discharge but no sarcopenia following CR (ie, improved), and patients with sarcopenia at discharge and following CR (ie, unimproved).METHODS:
Cox regression analysis was used to examine the risk of all-cause death associated with the 3 sarcopenia status groups.RESULTS:
Of 546 patients with HF (median age 70 years; male 63.6%), 377 (69.0%), 54 (9.9%), and 115 (21.1%) were classified as robust, improved, and unimproved, respectively. Multivariate Cox regression analysis showed that the unimproved group had a significantly greater risk of all-cause death when compared to the robust group [hazard ratio (HR) 2.603, 95% CI 1.375-4.930, P = .004], but it did not differ from the improved group (HR 1.403, 95% CI 0.598-3.293, P = .43). CONCLUSIONS AND IMPLICATIONS No improvement in sarcopenia status in patients with HF undergoing outpatient CR was associated with a higher risk of all-cause death. Sarcopenia may be an important target to improve the prognosis of patients with HF.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sarcopénie
/
Réadaptation cardiaque
/
Défaillance cardiaque
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites:
Aged
/
Humans
/
Male
Langue:
En
Journal:
J Am Med Dir Assoc
Sujet du journal:
HISTORIA DA MEDICINA
/
MEDICINA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Japon
Pays de publication:
États-Unis d'Amérique